Two migrant ranchers travel throughout California working on farms in hopes of one day saving enough money to own their own ranch. Yet things are simple for George Milton and Lennie Small. George is highly intelligent, but a cynic. And, Lennie is very large and mentally challenged. And, as the pair seem to get closer to their dream, a misunderstanding turns their story tragic.

Of Mice and Men is a widely read book in U.S. schools, but it is also on the American Library Association's list of the "Most Challenged Books of 21st Century" because of censorship issues.